{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester
CAS No.:913171-57-0
Molecular Formula:C₁₉H₃₀Br₂N₂O₃
Molecular Weight:494.267
Hs Code.:

{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

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Chemical Property of {3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

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Technology Process of {3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

There total 4 articles about {3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 913171-56-9
{3-[2,6-dibromo-4-(3-dimethylamino-prop-1-ynyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

: 913171-57-0
{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With formic acid; triethylamine; RhCl(PPh₃)3; In dimethyl sulfoxide; at 150 ℃; for 0.0166667h; microwave irradiation;
DOI:10.1021/ol061599w

Reference yield:

: 865722-93-6
[3-(2,6-dibromo-4-iodophenoxy)propyl]carbamic acid tert-butyl ester

: 913171-57-0
{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / CuI; TEA / Pd(PPh₃)4 / 4 h / 20 °C

2: 56 percent / formic acid; triethylamine / RhCl(PPh₃)3 / dimethylsulfoxide / 0.02 h / 150 °C / microwave irradiation

With copper(l) iodide; formic acid; TEA; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; RhCl(PPh₃)3; In dimethyl sulfoxide; 1: Sonogashira coupling;
DOI:10.1021/ol061599w

Reference yield:

: 540-38-5
p-Iodophenol

: 913171-57-0
{3-[2,6-dibromo-4-(3-dimethylamino-propyl)-phenoxy]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / N-bromo-tert-butylamine / 1,2-dichloro-benzene / 0.5 h / 0 °C

2: 98 percent / Cs₂CO₃; NaI / acetonitrile / 8 h / 65 °C

3: 71 percent / CuI; TEA / Pd(PPh₃)4 / 4 h / 20 °C

4: 56 percent / formic acid; triethylamine / RhCl(PPh₃)3 / dimethylsulfoxide / 0.02 h / 150 °C / microwave irradiation

With copper(l) iodide; formic acid; TEA; N-bromo-2-methylpropan-2-amine; caesium carbonate; triethylamine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; RhCl(PPh₃)3; In dimethyl sulfoxide; 1,2-dichloro-benzene; acetonitrile; 3: Sonogashira coupling;
DOI:10.1021/ol061599w