N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

Base Information

Chemical Name:N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine
CAS No.:1260244-32-3
Molecular Formula:C₂₈H₃₇N₃O₂
Molecular Weight:447.621
Hs Code.:

Synonyms:N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

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Chemical Property of N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

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Technology Process of N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

There total 8 articles about N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1319210-09-7
2-[4-(2-piperidin-1-ylethoxy)phenyl]quinolin-4-ol

: 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride

: 1260244-32-3
N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

Guidance literature:: 2-[4-(2-piperidin-1-ylethoxy)phenyl]quinolin-4-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-chloro-N,N-diethylethylamine hydrochloride; In N,N-dimethyl-formamide; at 110 ℃; for 5h;
DOI:10.1021/jm200370y

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1260244-32-3
N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 100 °C

2.1: sodium hydroxide / methanol / 15 h / 20 °C

3.1: thionyl chloride / Reflux

4.1: triethylamine / tetrahydrofuran / 3 h / 70 °C

5.1: potassium tert-butylate; tert-butyl alcohol / 72 h / 100 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 5 h / 110 °C

With thionyl chloride; potassium tert-butylate; potassium carbonate; triethylamine; sodium hydroxide; tert-butyl alcohol; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200370y

Reference yield:

: 1319210-03-1
N-(2-acetylphenyl)-4-(2-piperidin-1-ylethoxy)benzamide

: 1260244-32-3
N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate; tert-butyl alcohol / 72 h / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 5 h / 110 °C

With potassium tert-butylate; potassium carbonate; tert-butyl alcohol; In N,N-dimethyl-formamide;
DOI:10.1021/jm200370y