869-24-9Relevant articles and documents
Preparation method for high-yield N, N-diethylethylenediamine
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Paragraph 0019, (2018/12/14)
The invention discloses a preparation method for high-yield N, N-diethylethylenediamine. The method comprises the following steps that 2-diethylaminoethylchloride hydrochloride and benzyl carbamate are added into a sodium hydroxide solution, a palladium-carbon catalyst is added, heating is carried out so as to reach 55-65 DEG C for reaction for 4-7 hours under a sealed condition, alkali is added into reaction liquid for cooling and alkali precipitation, lower-layer alkali liquor and the palladium-carbon catalyst are separated, an organic layer is subjected to rectification treatment, and a fraction of 142-148 DEG C is collected so as to obtain the N,N-diethylethylenediamine. The method has the advantages that the reaction conditions are mild, no harmful gas is adopted or generated in the reaction process, and meanwhile, the yield of the N,N-diethylethylenediamine is high.
Preparation method of N,N-diethylenediamine
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Paragraph 0005; 0031-0033, (2018/08/04)
The invention belongs to the technical field of chemical synthesis and relates to a preparation method of N,N-diethylenediamine. The preparation method of the N,N-diethylenediamine comprises the following steps: (1) preparing 2-diethylamine-based chloroethane hydrochloride: performing heat-preserving reaction on a chlorinating agent and diethylamine ethanol in a reaction solvent, concentrating a reaction solvent after the heat-preserving reaction, adding low molecular alcohol or ester after concentrating, performing recrystallization to obtain a 2-2-diethylamine-based chloroethane hydrochloride wet product and drying to obtain a 2-diethylamine-based chloroethane hydrochloride dry product; (2) preparing the N,N-diethylenediamine: performing heat-preserving and pressure-maintaining reactionon the 2-diethylamine-based chloroethane hydrochloride and excessive liquid ammonia for more than or equal to 4 hours under the conditions that the pressure is 0 to 10 MPa and the temperature is 10 to100 DEG C, recycling the residual ammonia gas after the reaction, adding alkali into the reaction liquid, performing cooling alkali analysis, separating out the lower layer of alkaline liquid, rectifying an organic layer and collecting the fraction with the temperature of 143 to 148 DEG C, to obtain the N,N-diethylenediamine. The N,N-diethylenediamine prepared according to the method provided bythe invention has the advantages of high yield, high content, simplicity in operation, low raw material cost and the like.
Coumadin female phenol split-ring analogue and its medical use
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Paragraph 0045-0047, (2017/10/06)
The invention relates to the field of pharmaceutical chemistry, in particular to a coumestrol open-ring analogue with structures as shown in general formulae I and II and a medical application thereof, especially an application to the preparation of drugs as angiogenesis inhibition and vascular disruption agents.
Side chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides
Xiao, Chunsheng,Cheng, Yilong,Zhang, Yu,Ding, Jianxun,He, Chaoliang,Zhuang, Xiuli,Chen, Xuesi
, p. 671 - 679 (2014/02/14)
The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(l-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-l-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the "linkers" between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pHt) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the "linkers." TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched "linker" (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. Copyright
INDENOISOQUINOLINONE DERIVATIVES, MANUFACTURING METHOD AND MEDICAL USE THEREOF
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Paragraph 0060; 0061, (2013/04/13)
Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.
Aβ Aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides
Lin, Shwu-Jiuan,Shiao, Young-Ji,Chi, Chih-Wen,Yang, Li-Ming
, p. 1173 - 1176 (2007/10/03)
Phenylazo benzenesulfonamides were designed and synthesized as β-amyloid (Aβ40) fibril assembly inhibitors, and evaluated for inhibition of Aβ40 aggregation and neurotoxicity using rat cortical neurons. Compound 2 (LB-152) was the most potent compound in this study, and the para-NMe2 group on the end of the phenylazo moiety may play an important role in preventing Aβ40 fibril formation. LB-152 provides a new lead for further development of potential β-amyloid aggregation inhibitors to treat AD.
2,3-oxidosqualene-lanosterol cyclase inhibitors
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, (2008/06/13)
The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
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, (2008/06/13)
The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus infection.
Characteristics of immobilized β-galactosidase from Cicer Arietinum
Li, Xuyuan,Meng, Yanfa,Zhao, Kehao,Tu, Weixia
, p. 383 - 393 (2007/10/03)
Sephadex G-100 modified with chloracetic acid and CEAH was prepared into cationic and anionic carriers and activated by CNBr. β-Galactosidase I (β-D-galactoside galactohydrolase EC 3.2.1.23) isolated and partially purified from gram chicken bean was immobilized on modified Sephadex G-100 by means of adsorption and crosslinking reaction. Both the anionic and cationic gel carriers have high protein binding capacity and high yield of enzyme activity. Kinetic results showed that the enzyme activity attained its maximum at 57 °C for cationic carriers and 52 °C for anionic carriers. In addition, the operational pH range of the immobilized enzyme was increased. Storage stability of the immobilized enzyme preparations at room temperature was better than that of soluble enzyme. Results of the repeated batch experiments suggested that immobilized enzymes could be reused.
