N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Base Information

Chemical Name:N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid
CAS No.:1355326-36-1
Molecular Formula:C₂₇H₃₁FN₄O₂*ClH
Molecular Weight:499.028
Hs Code.:

Synonyms:N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Suppliers and Price of N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

There total 3 articles about N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1355326-35-0
AGI-5198

: 1355326-36-1
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; tert-butyl methyl ether; at 0 - 20 ℃; for 2h;
DOI:10.1021/ml300225h

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1355326-36-1
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 0.67 h / 20 °C

1.2: 0.33 h / 20 °C

1.3: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 20 °C / Reflux

3.1: hydrogenchloride / methanol; dichloromethane; tert-butyl methyl ether / 2 h / 0 - 20 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane; tert-butyl methyl ether; 1.1: |Ugi Condensation / 1.2: |Ugi Condensation / 1.3: |Ugi Condensation;
DOI:10.1021/ml300225h

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 1355326-36-1
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide hydrochloric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 0.67 h / 20 °C

1.2: 0.33 h / 20 °C

1.3: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 20 °C / Reflux

3.1: hydrogenchloride / methanol; dichloromethane; tert-butyl methyl ether / 2 h / 0 - 20 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane; tert-butyl methyl ether; 1.1: |Ugi Condensation / 1.2: |Ugi Condensation / 1.3: |Ugi Condensation;
DOI:10.1021/ml300225h