Technology Process of eudistomin Y13
There total 3 articles about eudistomin Y13 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
eudistomin Y12;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 1h;
Inert atmosphere;
Cooling with ice;
With
water; sodium hydroxide;
In
tetrahydrofuran;
Inert atmosphere;
Cooling with ice;
DOI:10.1016/j.bmc.2012.05.002
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Cooling with ice
1.2: Inert atmosphere; Cooling with ice
2.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice
3.2: Inert atmosphere; Cooling with ice
With
sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2012.05.002
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice
2.2: Inert atmosphere; Cooling with ice
With
lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2012.05.002