(S)-BICALUTAMIDE

Base Information

Chemical Name:(S)-BICALUTAMIDE
CAS No.:113299-38-0
Molecular Formula:C₁₈H₁₄F₄N₂O₄S
Molecular Weight:430.38
Hs Code.:
Mol file:113299-38-0.mol

Synonyms:Propanamide,N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-,(S)-; (S)-Casodex

Suppliers and Price of (S)-BICALUTAMIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-Bicalutamide
250mg
$ 700.00

Biosynth Carbosynth
(S)-Bicalutamide
10 mg
$ 125.00

Biosynth Carbosynth
(S)-Bicalutamide
5 mg
$ 80.00

Biosynth Carbosynth
(S)-Bicalutamide
2 mg
$ 50.00

Biosynth Carbosynth
(S)-Bicalutamide
50 mg
$ 250.00

Biosynth Carbosynth
(S)-Bicalutamide
25 mg
$ 200.00

AK Scientific
(S)-Bicalutamide
25mg
$ 320.00

AK Scientific
(S)-Bicalutamide
5mg
$ 158.00

Total 10 raw suppliers

Chemical Property of (S)-BICALUTAMIDE

Chemical Property:

Melting Point:175-179°C
Boiling Point:650.3±55.0 °C(Predicted)
PKA:11.49±0.29(Predicted)
PSA：115.64000
Density:1.52±0.1 g/cm3(Predicted)
LogP:4.03338
Storage Temp.:-20°C Freezer

Purity/Quality:

> 95% ^*data from raw suppliers

(S)-Bicalutamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (S)-Bicalutamide is the (S)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal)

Technology Process of (S)-BICALUTAMIDE

There total 11 articles about (S)-BICALUTAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: (R)-Thiobicalutamide

: 90357-06-5,113299-38-0,151262-58-7,113299-40-4
(R)-bicalutamide

Guidance literature:: With sodium tungstate; dihydrogen peroxide; In acetone; at 5 ℃; Reflux;

Reference yield: 91.0%

: 890658-79-4
C₁₀H₁₁FO₅S

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 90357-06-5,113299-38-0,151262-58-7,113299-40-4
(R)-bicalutamide

Guidance literature:: With thionyl chloride; In tetrahydrofuran; at 20 ℃; for 120h;
DOI:10.1016/j.tetlet.2006.12.011

Reference yield:

: 824-80-6
sodium 4-fluorobenzenesulfinate

: 90357-06-5,113299-38-0,151262-58-7,113299-40-4
(R)-bicalutamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-hydroxyphthalimide; diisopropyl-carbodiimide; dmap / dichloromethane / 20 °C / Sealed tube

1.2: 12 h / 20 °C / Inert atmosphere; Irradiation

2.1: potassium hydroxide / methanol; water / 2 h / 220 °C

3.1: N,N-dimethyl acetamide / 3 h / -10 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With dmap; N-hydroxyphthalimide; N,N-dimethyl acetamide; potassium hydroxide; diisopropyl-carbodiimide; In methanol; dichloromethane; water;
DOI:10.1016/j.chempr.2020.02.003