824-80-6

Basic information

• Product Name: 4-FLUOROBENZENESULFINIC ACID SODIUM SALT
• Synonyms: 4-FLUOROBENZENESULFINIC ACID SODIUM SALT;SODIUM P-FLUOROBENZENE SULFINATE;p-Fluorobenzenesulfinic Acid Sodium Salt Dihydrate;4-Flurobenzenesulfinic acid sodium salt;Sodium4fluorobenzenesulfinate,4-FLUOROBENZENESULFINICACIDSODIUMSALT;NSC 131873;Fluorobenzaldehyde Sodium
• CAS NO: 824-80-6
• Molecular Formula: C₆H₄FO₂S*Na
• Molecular Weight: 182.15
• Mol File: 824-80-6.mol
• Article Data: 49

Chemical Properties

• Melting Point: >250°C
• Boiling Point: 329.5 °C at 760 mmHg
• Flash Point: 153.1°C
• Appearance: /
• Vapor Pressure: 7.09E-05mmHg at 25°C
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-FLUOROBENZENESULFINIC ACID SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZENESULFINIC ACID SODIUM SALT(824-80-6)
• EPA Substance Registry System: 4-FLUOROBENZENESULFINIC ACID SODIUM SALT(824-80-6)

Safety Data

• Hazardous Substances Data: 824-80-6(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C6H5FO2S.Na/c7-5-1-3-6(4-2-5)10(8)9;/h1-4H,(H,8,9);/q;+1/p-1

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 371-42-6 4-Fluorothiophenol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 139131-32-1 Potassium p-Fluorobenzenethiosulfonic Acid 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 139131-31-0 β-(Diisopropylamino)ethyl p-fluorobenzenethiosulfonate 
• 462-06-6 fluorobenzene 

Downstream Products

• 368-85-4 4-fluorobenzenesulfonyl fluoride 
• 74321-38-3 p-Fluorbenzolsulfinsaeurefluorid 
• 139211-50-0 (3S,4R)-3-<(1R)-1-<<(1,1-dimethylethyl)-dimethylsilyl>oxy>ethyl>-2-oxo-4-<3-<(4-fluorophenyl)-sulfonyl>-2-iodo-2(E)-propenyl>-1-azetidineacetic acid,(4-nitrophenyl)methyl ester 
• 312-31-2 4-(phenylsulfonyl)fluorobenzene 
• 933796-07-7 8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-fluorophenyl)sulfonyl]quinoline 
• 104517-38-6 1-fluoro-4-((2-methylbut-3-en-2-yl)sulfonyl)benzene 
• 1194551-63-7 5-((4-fluorophenylsulfonyl)methyl)thiazol-2-amine 
• 1629-26-1 2-(4-fluorophenyl)-benzothiazole 
• 1394124-53-8 S-benzyl 4-fluorobenzenesulfonothioate 
• 1394124-50-5 4-fluorobenzenethiosulfonic acid S-p-tolyl ester 
• 1394124-52-7 S-3-nitrophenyl-4-fluorobenzenesulfonothioate 
• 2905-15-9 1-fluoro-4-[(4-fluorobenzenesulfonyl)sulfanyl]benzene 
• 1394124-51-6 S-2-fluorophenyl 4-fluorobenzenesulfonothioate 
• 1415245-44-1 S-(4-bromophenyl) 4-fluorobenzenesulfonothioate 

Relevant articles and documents

Visible-light-promotedE-selective synthesis of α-fluoro-β-arylalkenyl sulfidesviathe deoxygenation/isomerization process

Regioselective synthesis of α-fluoro-β-arylalkenyl sulfides has been established withgem-difluoroalkenes and sodium sulfinates in a transition-metal-free manner. A series of control experiments were executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselectiveZ→Eisomerization was achieved under green light irradiation in the absence of a photoinitiator.

A three-component reaction of arynes, sodium sulfinates, and aldehydes toward 2-sulfonyl benzyl alcohol derivatives

A novel three-component reaction of arynes, sodium sulfinates, and aldehydes under mild reaction conditions is described. This transformation provides a direct synthetic approach to 2-sulfonyl benzyl alcohol derivatives, which could be rapidly converted to diverse arylsulfur compounds via the transformation of the corresponding hydroxyl groups. Various aryne precursors, sodium arenesulfinates, and aromatic aldehydes can be effectively converted to the desired products in 40-84% yields (29 examples).

Visible-light-driven electron donor-acceptor complex induced sulfonylation of diazonium salts with sulfinates

This work reports an efficient sulfonylation reaction enabled by a visible-light-induced radical coupling reaction between phenyl/heterocyclic diazonium salts and sulfinates. Mechanistic experiments disclosed the formation of a versatile electron donor-acceptor (EDA) complex. This transformation is characterized by an easy operational procedure under mild conditions which avoids transition metals, ligands, catalysts, and oxidants.