N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

Base Information

Chemical Name:N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide
CAS No.:1447525-11-2
Molecular Formula:C₃₃H₃₅N₃O₅S
Molecular Weight:585.724
Hs Code.:

Synonyms:N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

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Chemical Property of N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

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Technology Process of N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

There total 3 articles about N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 590-93-2
2-Butynoic acid

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 2393-23-9
4-methoxy-benzylamine

: 79681-04-2
1-[(4-methyl-phenyl)-sulfonyl]-1H-indol-4-carboxaldehyde

: 1447525-11-2
N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

Guidance literature:: With methanol; sodium sulfate; at 50 ℃;
DOI:10.1039/c3cc42704h

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1447525-11-2
N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.5 h / 5 - 10 °C

2: sodium sulfate; methanol / 50 °C

With methanol; tetra(n-butyl)ammonium hydrogensulfate; sodium sulfate; sodium hydroxide; In dichloromethane; 2: |Ugi Condensation;
DOI:10.1039/c3cc42704h

Reference yield:

: 1074-86-8
4-formyl indole

: 1447525-11-2
N-(2-(tert-butylamino)-2-oxo-1-(1-tosyl-1H-indol-4-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.5 h / 5 - 10 °C

2: sodium sulfate; methanol / 50 °C

With methanol; tetra(n-butyl)ammonium hydrogensulfate; sodium sulfate; sodium hydroxide; In dichloromethane; 2: |Ugi Condensation;
DOI:10.1039/c3cc42704h