(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Base Information

Chemical Name:(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol
CAS No.:1202577-83-0
Molecular Formula:C₂₁H₂₃F₃O₃
Molecular Weight:380.407
Hs Code.:

Synonyms:(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

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Chemical Property of (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

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Technology Process of (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

There total 16 articles about (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoate

: 1202577-83-0
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.25h; Inert atmosphere;
DOI:10.1021/ml500391n

Reference yield: 63.0%

: 1202577-82-9
(1S)-4-(trifluoromethyl)indan-1-ol

: 1202577-78-3
4-{(1S)-1-ethoxy-3-[(triisopropylsilyl)oxy]propyl}phenol

: 1202577-83-0
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Guidance literature:: (1S)-4-(trifluoromethyl)indan-1-ol; 4-{(1S)-1-ethoxy-3-[(triisopropylsilyl)oxy]propyl}phenol; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 - 50 ℃; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: C₃₀H₄₃F₃O₃Si

: 1202577-83-0
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 40 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2015.07.028