(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Base Information

Chemical Name:(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid
CAS No.:1202575-67-4
Molecular Formula:C₂₁H₂₁F₃O₄
Molecular Weight:394.391
Hs Code.:

Synonyms:(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Suppliers and Price of (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Chemical Property:

Boiling Point:469.0±45.0 °C(Predicted)
Density:1.290±0.06 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

There total 17 articles about (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1202577-83-0
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

: 1202575-67-4
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Guidance literature:: (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol; With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In aq. phosphate buffer; water; acetonitrile; at 0 - 10 ℃; for 1.5h; pH=6.8;

With sodium thiosulfate; sodium hydroxide; In aq. phosphate buffer; water; toluene; acetonitrile; at 0 ℃; for 0.333333h;
DOI:10.1021/ml500391n

Reference yield:

: 68755-42-0
4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one

: 1202575-67-4
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; formic acid / (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-ruthenium(mesitylene) / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile / 2.5 h / 0 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; formic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-ruthenium(mesitylene); In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1202577-76-1
(1S)-1-(4-benzyloxyphenyl)-3-(triisopropylsilyloxy)propan-1-ol

: 1202575-67-4
(3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

3.2: 0 - 20 °C

4.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile / 2.5 h / 0 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;