ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate

Base Information

• Chemical Name: ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate
• CAS No.: 168909-69-1
• Molecular Formula: C₁₇H₂₆ClO₄P
• Molecular Weight: 360.818
• Mol file: 168909-69-1.mol

Synonyms:ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate

Chemical Property of ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate

There total 2 articles about ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Propa-1,2-dienyl-phosphinic acid ethyl ester (133457-90-6) → ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate (168909-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / BF₃*Et₂O / 24 h / Ambient temperature

2: 1.) Mg, 2.) CuBr*Me₂S / 1.) Et₂O, reflux, 1 h, 2.) Et₂O, Me₂S, from -45 deg C to -20 deg C, 4 h

With copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate; magnesium;

DOI:10.1021/jm00017a015

Reference yield:

1-Chloro-4-iodobenzene (637-87-6) + ethyl (1,1-diethoxyethylpropa-1,2-dienyl)phosphinate (133457-91-7) → ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate (168909-69-1)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; magnesium; Yield given. Multistep reaction; 1.) Et₂O, reflux, 1 h, 2.) Et₂O, Me₂S, from -45 deg C to -20 deg C, 4 h;

DOI:10.1021/jm00017a015

Reference yield: 70.0%

ethyl <2-(4-chlorophenyl)propen-2-yl>(1,1-diethoxyethyl)phosphinate (168909-69-1) → ethyl <2-(4-chlorophenyl)propen-2-yl>phosphinate (168910-00-7)

Guidance literature:

With chloro-trimethyl-silane; ethanol; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jm00017a016

upstream raw materials:

1-Chloro-4-iodobenzene

ethyl (1,1-diethoxyethylpropa-1,2-dienyl)phosphinate

Propa-1,2-dienyl-phosphinic acid ethyl ester

Downstream raw materials:

ethyl <2-(4-chlorophenyl)propen-2-yl>phosphinate

ethyl <2-(4-chlorophenyl)prop-1-enyl>methylphosphinate

ethyl <2-(4-chlorophenyl)propen-2-yl>n-butylphosphinate

ethyl <3-<(tert-butoxycarbonyl)amino>-2-(4-chlorophenyl)-2-hydroxypropyl>n-butylphosphinate