3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

Base Information

Chemical Name:3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester
CAS No.:299185-06-1
Molecular Formula:C₂₂H₃₂O₅SSi
Molecular Weight:436.645
Hs Code.:

3-benzenesulfonyl-2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

Synonyms:3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

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Chemical Property of 3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

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Technology Process of 3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

There total 1 articles about 3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 116830-92-3
2-(chloromethyl)-3-(phenylsulfonyl)-1-propene

: 80866-51-9
ethyl 4-((tert-butyldimethylsilyl)oxy)but-2-ynoate

: 299185-06-1
3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; at -60 ℃; for 4h;
DOI:10.1016/S0040-4039(00)00867-4

Reference yield: 89.0%

: 299185-06-1
3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

: 299185-20-9
4-benzenesulfonyl-5-methylene-3,4,5,6-tetrahydro-cyclopenta[c]furan-1-one

Guidance literature:: 3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester; With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 4h;

toluene-4-sulfonic acid; In benzene; for 2h; Heating;
DOI:10.1016/S0040-4039(00)00867-4

Reference yield:

: 299185-06-1
3-benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methylene-cyclopent-1-enecarboxylic acid ethyl ester

: 4-benzenesulfonyl-5-methyl-3,6-dihydro-cyclopenta[c]furan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / tetrahydrofuran / 4 h / 20 °C

1.2: 89 percent / p-TSA / benzene / 2 h / Heating

2.1: Na₂CO₃ / H₂O; tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; sodium carbonate; In tetrahydrofuran; water; 1.1: Hydrolysis / 1.2: Cyclization / 2.1: Rearrangement;
DOI:10.1016/S0040-4039(00)00867-4