N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Base Information

Chemical Name:N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide
CAS No.:173677-70-8
Molecular Formula:C₂₅H₂₃NO₄
Molecular Weight:401.462
Hs Code.:

N-<2-(6,11-dihydro-11-oxodibenz<b,e>oxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Synonyms:N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Suppliers and Price of N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

There total 11 articles about N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)ethylamine hydrochloride

: 75-36-5
acetyl chloride

: 173677-70-8
N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 173677-70-8
N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: K₂CO₃, KI / butan-2-one / 24 h / Heating

2: KOH / aq. ethanol / Heating

3: 1.) (CF₃CO)2O, 2.) 10percent aq. HCl / 1.) CH₂Cl₂, reflux, 4 h, 2.) acetone, reflux, 24 h

4: 59 percent / borane / tetrahydrofuran / 72 h / Ambient temperature

5: Et₃N

6: 54 percent / NaH / dimethylformamide / 100 °C

7: HCl / ethyl acetate; diethyl ether / 0.17 h

8: Et₃N / tetrahydrofuran / 2 h

With hydrogenchloride; potassium hydroxide; borane; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic anhydride; potassium iodide; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm950563z

Reference yield:

: 55453-87-7
isoxepac

: 173677-70-8
N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / borane / tetrahydrofuran / 72 h / Ambient temperature

2: Et₃N

3: 54 percent / NaH / dimethylformamide / 100 °C

4: HCl / ethyl acetate; diethyl ether / 0.17 h

5: Et₃N / tetrahydrofuran / 2 h

With hydrogenchloride; borane; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950563z