<2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

Base Information

Chemical Name:<2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid
CAS No.:89578-75-6
Molecular Formula:C₃₀H₅₂N₂O₅SSi
Molecular Weight:580.905
Hs Code.:

Synonyms:<2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

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Chemical Property of <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

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Technology Process of <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

There total 18 articles about <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 89578-74-5
methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

: 89578-75-6
<2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

Guidance literature:: With lithium hydroxide; In methanol; for 15h; Ambient temperature;
DOI:10.1021/ja00323a030

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 89578-75-6
<2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C

2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

With pyridine; lithium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/ja00323a030

Reference yield:

: 72952-73-9
(E)-2,4-pentadienyltrimethylsilane

: 89578-75-6
<2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetic acid

Guidance literature:: Multi-step reaction with 14 steps

1: 69 percent / TiCl₄ / CH₂Cl₂ / -41 °C

2: 95 percent / trifluoroacetic acid / 24 h

3: 82 percent / acetone / 72 h / Heating

4: 97 percent / pyridine / 12 h

5: 83 percent / diisopropyl-ethylamine / toluene / 3 h / 215 °C

6: 96 percent / 5percent NaOH / methanol / 2 h / Ambient temperature

7: oxalyl chloride / toluene / 3 h / Ambient temperature

8: diethyl ether / 1 h / Ambient temperature

9: Ag₂O / 12 h

10: Ba(OH)2*8H₂O / various solvent(s); H₂O / 48 h / Heating

11: SOCl₂ / 12 h / Heating

12: 91 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / 0 °C

13: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

14: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

With 2,6-dimethylpyridine; barium dihydroxide; lithium hydroxide; sodium hydroxide; thionyl chloride; oxalyl dichloride; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In pyridine; methanol; diethyl ether; dichloromethane; water; acetone; toluene; trifluoroacetic acid;
DOI:10.1021/ja00323a030