Technology Process of 5-(1,1-dioxo-2,3-dihydro-1,3-benzothiazole-3-carbonyl)-2-methoxy-3-trifluoromethylbenzoic acid
There total 15 articles about 5-(1,1-dioxo-2,3-dihydro-1,3-benzothiazole-3-carbonyl)-2-methoxy-3-trifluoromethylbenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; 2-methyl-but-2-ene; citric acid;
In
methanol; water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C
1.2: 1 h / 0 °C
1.3: 16 h / 20 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 6.5 h / 60 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C
4.1: Amberlyst-15 / ethanol / 3.5 h / Reflux
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C
6.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C
7.1: sodium chlorite; 2-methyl-but-2-ene; citric acid / methanol; water / 1 h / 20 °C
With
hydrogenchloride; sodium chlorite; thionyl chloride; 2-methyl-but-2-ene; magnesium; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; citric acid;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / N,N-dimethyl-formamide / toluene / 6.5 h / 60 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C
3: Amberlyst-15 / ethanol / 3.5 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C
5: hydrogenchloride / ethyl acetate / 2 h / 20 °C
6: sodium chlorite; 2-methyl-but-2-ene; citric acid / methanol; water / 1 h / 20 °C
With
hydrogenchloride; sodium chlorite; thionyl chloride; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; citric acid;
N,N-dimethyl-formamide;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;
