N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido

Base Information

• Chemical Name: N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido
• CAS No.: 246033-26-1
• Molecular Formula: C₂₀H₂₃NO₇S
• Molecular Weight: 421.471
• Mol file: 246033-26-1.mol

Synonyms:N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido

Chemical Property of N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido

There total 3 articles about N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Methyl 2-bromopropionate (5445-17-0) + N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido (246033-23-8) → N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido (246033-26-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 36h;

DOI:10.1016/S0031-6865(99)00004-7

Reference yield:

tyramine hydrochloride (60-19-5) → N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido (246033-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 10 percent aq. NaHCO₃ / ethyl acetate / 2 h / 20 °C

2: 74 percent / K₂CO₃ / acetone / 36 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; In ethyl acetate; acetone; 1: Substitution / 2: Alkylation;

DOI:10.1016/S0031-6865(99)00004-7

Reference yield:

2-methyl-4,5-methylenedioxy-phenyl-sulfonyl chloride (246033-22-7) → N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido (246033-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 10 percent aq. NaHCO₃ / ethyl acetate / 2 h / 20 °C

2: 74 percent / K₂CO₃ / acetone / 36 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; In ethyl acetate; acetone; 1: Substitution / 2: Alkylation;

DOI:10.1016/S0031-6865(99)00004-7

upstream raw materials:

Methyl 2-bromopropionate

N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido

tyramine hydrochloride

2-methyl-4,5-methylenedioxy-phenyl-sulfonyl chloride