N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido

Base Information

• Chemical Name: N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido
• CAS No.: 246033-23-8
• Molecular Formula: C₁₆H₁₇NO₅S
• Molecular Weight: 335.381
• Mol file: 246033-23-8.mol

Synonyms:N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido

Chemical Property of N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido

There total 1 articles about N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tyramine hydrochloride (60-19-5) + 2-methyl-4,5-methylenedioxy-phenyl-sulfonyl chloride (246033-22-7) → N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido (246033-23-8)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/S0031-6865(99)00004-7

Reference yield: 74.0%

Methyl 2-bromopropionate (5445-17-0) + N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido (246033-23-8) → N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido (246033-26-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 36h;

DOI:10.1016/S0031-6865(99)00004-7

Reference yield: 37.0%

ethyl bromoacetate (105-36-2) + N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido (246033-23-8) → {4-[2-(6-methyl-benzo[1,3]dioxole-5-sulfonylamino)-ethyl]-phenoxy}-acetic acid ethyl ester + [[2-(4-ethoxycarbonylmethoxy-phenyl)-ethyl]-(6-methyl-benzo[1,3]dioxole-5-sulfonyl)-amino]-acetic acid ethyl ester

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 24h;

DOI:10.1016/S0031-6865(99)00004-7

upstream raw materials:

tyramine hydrochloride

2-methyl-4,5-methylenedioxy-phenyl-sulfonyl chloride

Downstream raw materials:

N-{2-[4-(1-methoxycarbonylethoxy)phenyl]ethyl}-6-methyl-3,4-methylenedioxyphenyl sulfonamido