3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

Base Information

Chemical Name:3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester
CAS No.:1011263-84-5
Molecular Formula:C₁₇H₂₆N₂O₃
Molecular Weight:306.405
Hs Code.:

Synonyms:3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

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Chemical Property of 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

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Technology Process of 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

There total 10 articles about 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011264-27-9
3-(4-cyano-2-ethyl-6-methyl-phenyl)-propionic acid tert-butyl ester

: 1011263-84-5
3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In methanol; for 7h; Heating / reflux;

Reference yield:

: 1011263-85-6
3-ethyl-4-hydroxy-5-methyl-benzoic acid benzyl ester

: 1011263-84-5
3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

2.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 3 h / 115 °C

3.1: hydrogen / palladium on carbon / tetrahydrofuran / 48 h / 20 °C / 750.08 Torr

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol / 1 h / 20 °C

4.2: 1 h / 20 °C

5.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1 h / 5 - 20 °C / Exothermic reaction

6.1: hydroxylamine hydrochloride; triethylamine / methanol / 7 h / Heating / reflux

With pyridine; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; palladium diacetate; palladium on carbon; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1011263-87-8
4-(2-tert-butoxycarbonyl-vinyl)-3-ethyl-5-methyl-benzoic acid benzyl ester

: 1011263-84-5
3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on carbon / tetrahydrofuran / 48 h / 20 °C / 750.08 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1 h / 5 - 20 °C / Exothermic reaction

4.1: hydroxylamine hydrochloride; triethylamine / methanol / 7 h / Heating / reflux

With hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;