Technology Process of 4-(2-tert-butoxycarbonyl-ethyl)-3-ethyl-5-methyl-benzoic acid
There total 6 articles about 4-(2-tert-butoxycarbonyl-ethyl)-3-ethyl-5-methyl-benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on carbon;
In
tetrahydrofuran;
at 20 ℃;
for 48h;
under 750.075 Torr;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium chlorite; sodium dihydrogenphosphate / water; dimethyl sulfoxide / 25 h / 20 - 40 °C / Exothermic; Cooling with ice-bath
1.2: pH 2 - 3
2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 18 h / 50 °C
3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C
4.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 3 h / 115 °C
5.1: hydrogen / palladium on carbon / tetrahydrofuran / 48 h / 20 °C / 750.08 Torr
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; hydrogen; potassium hydrogencarbonate; triethylamine;
palladium diacetate; palladium on carbon; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C
1.2: 18 h / 20 °C
2.1: water; acetic acid / 3 h / 115 - 117 °C / Heating / reflux
3.1: sodium chlorite; sodium dihydrogenphosphate / water; dimethyl sulfoxide / 25 h / 20 - 40 °C / Exothermic; Cooling with ice-bath
3.2: pH 2 - 3
4.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 18 h / 50 °C
5.1: pyridine / dichloromethane / 2 h / 0 - 20 °C
6.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 3 h / 115 °C
7.1: hydrogen / palladium on carbon / tetrahydrofuran / 48 h / 20 °C / 750.08 Torr
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; sulfuric acid; water; hydrogen; potassium hydrogencarbonate; acetic acid; triethylamine; sodium nitrite;
palladium diacetate; palladium on carbon; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
