3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

Base Information

Chemical Name:3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester
CAS No.:512197-03-4
Molecular Formula:C₁₉H₃₀O₅
Molecular Weight:338.444
Hs Code.:

Synonyms:3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

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Chemical Property of 3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

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Technology Process of 3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

There total 4 articles about 3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-64-1
acetone

: 512196-74-6
4-(4-methoxybenzyloxy)butyric acid tert-butyl ester

: 512197-03-4
3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

Guidance literature:: 4-(4-methoxybenzyloxy)butyric acid tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

acetone; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;
DOI:10.1021/ol0275264

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 512197-03-4
3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / potassium hydroxide / dimethylsulfoxide / 2 h / 0 °C

2.1: 97 percent / Jones reagent / acetone / 1.5 h

3.1: 57 percent / CH₂Cl₂ / 40 h / -20 - 20 °C

4.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 100 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

With potassium hydroxide; jones reagent; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; acetone; 2.1: Jones oxidation;
DOI:10.1021/ol0275264

Reference yield:

: 119649-45-5
4-(p-methoxybenzyloxy)butan-1-ol

: 512197-03-4
3-hydroxy-2-[2-(4-methoxybenzyloxy)ethyl]-3-methylbutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / Jones reagent / acetone / 1.5 h

2.1: 57 percent / CH₂Cl₂ / 40 h / -20 - 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 100 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

With jones reagent; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetone; 1.1: Jones oxidation;
DOI:10.1021/ol0275264