(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

Base Information

Chemical Name:(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide
CAS No.:1266347-57-2
Molecular Formula:C₃₀H₃₃N₃O₃S
Molecular Weight:515.676
Hs Code.:

Synonyms:(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

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Technology Process of (S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

There total 5 articles about (S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₄N₂O₄S

: 103-67-3
benzyl-methyl-amine

: 1266347-57-2
(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/ol103105q

Reference yield:

: (2S)-2-amino-3-(1-methyl-1H-indol-3-yl)propionic acid methyl ester hydrochloride

: 1266347-57-2
(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 6 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C

2.2: 6 h / 60 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol103105q

Reference yield:

: 1266347-50-5
(S)-methyl 2-(N-(but-3-en-1-yl)phenylsulfonamido)-3-(1-methyl-1H-indol-3-yl)propanoate

: 1266347-57-2
(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol103105q