(S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate

Base Information

• Chemical Name: (S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate
• CAS No.: 1266347-77-6
• Molecular Formula: C₁₉H₂₀N₂O₄S
• Molecular Weight: 372.445
• Mol file: 1266347-77-6.mol

Synonyms:(S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate

Chemical Property of (S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate

There total 1 articles about (S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S)-2-amino-3-(1-methyl-1H-indol-3-yl)propionic acid methyl ester hydrochloride + benzenesulfonyl chloride (98-09-9) → (S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate (1266347-77-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ol103105q

Reference yield: 100.0%

(S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate (1266347-77-6) + allyl bromide (106-95-6) → (S)-methyl 2-(N-allylphenylsulfonamido)-3-(1-methyl-1H-indol-3-yl)propanoate (1266347-49-2)

Guidance literature:

(S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/ol103105q

Reference yield: 63.0%

1-bromo-4-butene (5162-44-7) + (S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate (1266347-77-6) → (S)-methyl 2-(N-(but-3-en-1-yl)phenylsulfonamido)-3-(1-methyl-1H-indol-3-yl)propanoate (1266347-50-5)

Guidance literature:

(S)-methyl 3-(1-methyl-1H-indol-3-yl)-2-(phenylsulfonamido)propanoate; With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

1-bromo-4-butene; In N,N-dimethyl-formamide; at 60 ℃; for 6h;

DOI:10.1021/ol103105q

upstream raw materials:

benzenesulfonyl chloride

Downstream raw materials:

(S)-methyl 2-(N-(but-3-en-1-yl)phenylsulfonamido)-3-(1-methyl-1H-indol-3-yl)propanoate

(S)-2-(N-allylphenylsulfonamido)-N-benzyl-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

(S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N-methyl-3-(1-methyl-1H-indol-3-yl)propanamide

(1R,2S,5S)-N-benzyl-N-methyl-2-((1-methyl-1H-indol-3-yl)methyl)-3-(phenylsulfonyl)-3-azabicyclo[3.1.0]hexan-1-amine