(R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

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Chemical Name:(R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one
CAS No.:207515-66-0
Molecular Formula:C₃₅H₄₄O₄S₂Si
Molecular Weight:620.949
Hs Code.:

Synonyms:(R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

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Chemical Property of (R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

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Technology Process of (R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

There total 6 articles about (R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3866-79-3
1,3-bis(p-toluenesulfonylthio)propane

: 207515-65-9
(R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-(3,4-dimethoxy-phenyl)-cyclohexanone

: 207515-66-0
(R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol;
DOI:10.1039/a709212a

Reference yield:

: 207515-62-6
(1S,4R,4aS,8aR)-7-(2-Benzyloxy-ethyl)-4,4a,8,8a-tetrahydro-1H-1,4-methano-naphthalen-5-one

: 207515-66-0
(R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) CuBr*SMe₂, Me₃SiCl, HMPA, 2.) acid / 1.) THF

2: diphenyl ether / 260 °C

3: DIBAL-H, CuI, HMPA / tetrahydrofuran

4: H₂ / 10percent Pd/C

5: imidazole / dimethylformamide

6: 70 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; diphenylether; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/a709212a

Reference yield:

: 207515-64-8
(R)-5-(2-Benzyloxy-ethyl)-5-(3,4-dimethoxy-phenyl)-cyclohex-2-enone

: 207515-66-0
(R)-9-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-9-(3,4-dimethoxy-phenyl)-1,5-dithia-spiro[5.5]undecan-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: DIBAL-H, CuI, HMPA / tetrahydrofuran

2: H₂ / 10percent Pd/C

3: imidazole / dimethylformamide

4: 70 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/a709212a