3866-79-3

Usage

Uses

Used in Pharmaceutical Industry:
Trimethylene Di(thiotosylate) is used as a reactant in the enantioselective total synthesis of (-)-O-methylpallidinine, which is a naturally occurring morphinan alkaloid. This application is significant because it contributes to the development of new drugs and pharmaceuticals, particularly those derived from natural sources.
In the synthesis of (-)-O-methylpallidinine, Trimethylene Di(thiotosylate) plays a crucial role in the formation of the desired product with high enantiomeric purity. This is important for the pharmaceutical industry as the biological activity of a drug can be significantly influenced by its stereochemistry. The use of Trimethylene Di(thiotosylate) in this process helps to ensure that the final product has the desired properties and is effective for its intended application.

InChI:InChI=1/C17H20O4S4/c1-14-4-8-16(9-5-14)24(18,19)22-12-3-13-23-25(20,21)17-10-6-15(2)7-11-17/h4-11H,3,12-13H2,1-2H3

Upstream product

• 3753-27-3 sodium 4-methylbenzenesulfonothioate 
• 109-64-8 1,3-dibromo-propane 
• 109-80-8 1.3-propanedithiol 
• 98-59-9 p-toluenesulfonyl chloride 
• 557-22-2 1,2-dithiolane 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 36106-46-4 4-[1,3]dithian-2-yl-nicotinonitrile 
• 58491-76-2 (6'R)-7't-benzoylamino-3'-methyl-5't,8'-dioxo-(6'rH)-5'λ⁴-spiro[[1,3]dithiane-2,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid methyl ester 
• 58491-77-3 (6R,6'R)-7t,7't'-bis-benzoylamino-3,3'-dimethyl-5t,8,5't',8'-tetraoxo-4c,4'c'-propane-1,3-diylbissulfanyl-bis-((6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid) dimethyl ester 
• 128432-45-1 (R)-2-(3-Methoxy-phenyl)-2-methyl-6,10-dithia-spiro[4.5]decan-1-one 
• 126412-20-2 (methoxymethylenoxy-2' phenyl)-3 (dithio-1,3 propyl)-6 cyclohexen-2 one 
• 95305-46-7 benzyl 4-ethyl-3-methyl-5-<2-(3-methyl-1-oxobut-2-enyl)-1,3-dithian-2-yl>pyrrole-2-carboxylate 
• 126412-26-8 (methoxymethylenoxy-2' fluoro-3' phenyl)-3 (dithio-1,3 propyl)-6 cyclohexen-2 one 
• 164229-09-8 (S)-3-((R)-1-Benzyloxymethyl-allyl)-6,10-dithia-spiro[4.5]decan-1-one 
• 189952-71-4 Benzyl-[2-((S)-4-oxo-6,10-dithia-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 188000-77-3 C₂₆H₃₉NO₄S₂Si 
• 319906-94-0 (+)-(4R)-4-[(1R)-2-Benzyloxy-1-vinylethyl]-2,2-propanedithiocyclopentan-1-one 
• 1391978-98-5 2'-((2-azidoethyl)(4-methoxybenzyl)amino)-1'H-spiro[[1,3]dithiane-2,4'-isoquinoline]-1',3'(2'H)-dione 
• 1391978-74-7 2'-((2-azidoethyl)(benzyl)amino)-1'H-spiro[[1,3]dithiane-2,4'-isoquinoline]-1',3'(2'H)-dione 
• 871365-77-4 N-(2,2-diethoxyethyl)-N-phenyl malonamide 2-(1,3-trimethylene)dithioketal 

Relevant academic research and scientific papers

A convenient one-pot preparation of stable equivalents of cyclobutane-1,2-dione and cyclobutanetrione

A very short, high-yielding, one-pot procedure has been developed for the preparation of half-protected cyclobutane-1,2-dione. This compound is much more stable than cyclobutane-1,2-dione itself and allowed further transformation to give diprotected cyclobutanetrione equivalents. Copyright Taylor & Francis Group, LLC.

New and facile synthesis of thiosulfonates from sulfinate/disulfide/I2 system

Thiosulfonates were prepared by the iodine oxidative sulfenylation of sulfinates with various disulfides in good yields both in the presence and absence of solvent. One of the important biological applications of sulfenylation is the reaction of cyclic disulfides.