3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

Base Information

Chemical Name:3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde
CAS No.:1307813-62-2
Molecular Formula:C₂₁H₁₁F₃N₂O₄
Molecular Weight:412.325
Hs Code.:

Synonyms:3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

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Chemical Property of 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

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Technology Process of 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

There total 14 articles about 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: C₂₂H₁₅F₃N₂O₅

: 1307813-62-2
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

Guidance literature:: With sodium periodate; In water; at 20 ℃; for 1h;

Reference yield:

: 1236188-87-6
5-phenyl-4-(trifluoromethyl)isoxazole-3-carboxylic acid

: 1307813-62-2
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 1 h / -78 °C

2.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

3.1: triphenylphosphine / dichloromethane / 0.08 h / 0 °C

3.2: 0.33 h / 0 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

4.2: 0.08 h / 20 °C

5.1: phosphorus tribromide / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Reflux

8.1: triethylamine; sodium hypochlorite / dichloromethane / 2 h / 0 - 20 °C

9.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

10.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water / 5 h / 20 °C

11.1: sodium periodate / water / 1 h / 20 °C

With 4-methyl-morpholine; sodium hypochlorite; sodium periodate; osmium(VIII) oxide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; lithium chloride; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1307812-27-6
5-phenyl-4-(trifluoromethyl)isoxazole-3-carbaldehyde

: 1307813-62-2
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: triphenylphosphine / dichloromethane / 0.08 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

2.2: 0.08 h / 20 °C

3.1: phosphorus tribromide / dichloromethane / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Reflux

6.1: triethylamine; sodium hypochlorite / dichloromethane / 2 h / 0 - 20 °C

7.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

8.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water / 5 h / 20 °C

9.1: sodium periodate / water / 1 h / 20 °C

With sodium hypochlorite; sodium periodate; osmium(VIII) oxide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;