tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate
CAS No.:1307813-63-3
Molecular Formula:C₂₉H₂₆F₃N₃O₅
Molecular Weight:553.538
Hs Code.:

Synonyms:tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Suppliers and Price of tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

There total 17 articles about tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1236144-52-7
tert-butyl azetidine-3-carboxylate acetic acid salt

: 1307813-62-2
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde

: 1307813-63-3
tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Guidance literature:: tert-butyl azetidine-3-carboxylate acetic acid salt; 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno-[4,3-c]isoxazole-7-carbaldehyde; With methanol; titanium(IV)isopropoxide; acetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1307812-26-5
(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)methanol

: 1307813-63-3
tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

2.1: triphenylphosphine / dichloromethane / 0.08 h / 0 °C

2.2: 0.33 h / 0 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

3.2: 0.08 h / 20 °C

4.1: phosphorus tribromide / dichloromethane / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Reflux

7.1: triethylamine; sodium hypochlorite / dichloromethane / 2 h / 0 - 20 °C

8.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

9.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water / 5 h / 20 °C

10.1: sodium periodate / water / 1 h / 20 °C

11.1: methanol / titanium(IV)isopropoxide; acetic acid / dichloromethane / 1.5 h / 20 °C

11.2: 2 h / 20 °C

With methanol; sodium hypochlorite; sodium periodate; osmium(VIII) oxide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium(IV)isopropoxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1236188-87-6
5-phenyl-4-(trifluoromethyl)isoxazole-3-carboxylic acid

: 1307813-63-3
tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 1 h / -78 °C

2.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

3.1: triphenylphosphine / dichloromethane / 0.08 h / 0 °C

3.2: 0.33 h / 0 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

4.2: 0.08 h / 20 °C

5.1: phosphorus tribromide / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Reflux

8.1: triethylamine; sodium hypochlorite / dichloromethane / 2 h / 0 - 20 °C

9.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

10.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water / 5 h / 20 °C

11.1: sodium periodate / water / 1 h / 20 °C

12.1: methanol / titanium(IV)isopropoxide; acetic acid / dichloromethane / 1.5 h / 20 °C

12.2: 2 h / 20 °C

With 4-methyl-morpholine; methanol; sodium hypochlorite; sodium periodate; osmium(VIII) oxide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; lithium chloride; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium(IV)isopropoxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;