(2R,4S)-3-(tert-butoxycarbonyl)-2-tert-butyl-4-methyloxazolidine-4-carboxylic acid

Base Information

Chemical Name:(2R,4S)-3-(tert-butoxycarbonyl)-2-tert-butyl-4-methyloxazolidine-4-carboxylic acid
CAS No.:1179522-58-7
Molecular Formula:C₁₄H₂₅NO₅
Molecular Weight:287.356
Hs Code.:
Mol file:1179522-58-7.mol

Synonyms:(2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid

Suppliers and Price of (2R,4S)-3-(tert-butoxycarbonyl)-2-tert-butyl-4-methyloxazolidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of (2R,4S)-3-(tert-butoxycarbonyl)-2-tert-butyl-4-methyloxazolidine-4-carboxylic acid

Chemical Property:

Melting Point:117-118 °C
Boiling Point:387.4±42.0 °C(Predicted)
PKA:3.70±0.40(Predicted)
Density:1.127±0.06 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (2R,4S)-3-(tert-butoxycarbonyl)-2-tert-butyl-4-methyloxazolidine-4-carboxylic acid

There total 1 articles about (2R,4S)-3-(tert-butoxycarbonyl)-2-tert-butyl-4-methyloxazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (2S,4S)-3-tert-butyl 4-methyl 2-tert-butyl-4-methyl-1,3-oxazolidine-3,4-dicarboxylate

: 1179522-58-7,1686957-60-7
(2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid

Guidance literature:: With hydrogenchloride; lithium hydroxide monohydrate; In tetrahydrofuran; water; at 50 ℃; for 36h; Inert atmosphere;
DOI:10.1021/ol2018196

Reference yield: 82.0%

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 1179522-58-7,1686957-60-7
(2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid

: tert-butyl (2R,4S)-4-(4-((benzyloxy)carbonyl)piperazine-1-carbonyl)-2-(tert-butyl)-4-methyloxazolidine-3-carboxylate

Guidance literature:: (2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.25h;

phenylmethyl 1-piperazinecarboxylate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 79.0%

: 1179522-58-7,1686957-60-7
(2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid

: 619-45-4
4-methoxycarbonyl aniline

: C₂₂H₃₂N₂O₆

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1002/cjoc.202100284