4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

Base Information

Chemical Name:4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide
CAS No.:181696-17-3
Molecular Formula:C₁₇H₁₄F₂N₂O₃S
Molecular Weight:364.373
Hs Code.:

Synonyms:4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

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Chemical Property of 4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

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Technology Process of 4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

There total 7 articles about 4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1-(4-methylphenyl)-2-(4-aminosulfonylphenyl-ethan-1-one oxime

: bis(1,2-chlorodimethylsilyl)ethane

: 219679-74-0
3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole

: 454-31-9
ethyl difluoroacetate

: 181696-17-3
4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

Guidance literature:: With triethylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; water; ethyl acetate;

Reference yield: 10.0%

: 181697-27-8
1-(4-methylphenyl)-2-(4-aminosulfonylphenyl)-ethan-1-one oxime

: 454-31-9
ethyl difluoroacetate

: 181696-17-3
4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

Guidance literature:: 1-(4-methylphenyl)-2-(4-aminosulfonylphenyl)-ethan-1-one oxime; With 1,2-bis-(chlorodimethylsilyl)ethane; triethylamine; In tetrahydrofuran; at 20 ℃;

With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - -15 ℃;

ethyl difluoroacetate; With trifluoroacetic acid; more than 3 stages;

Reference yield:

: 100-39-0
benzyl bromide

: 181696-17-3
4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trimethylsilyl cyanide; zinc(II) iodide / dichloromethane / 4 h / 0 °C

1.2: 1 h / -78 - -60 °C

2.1: chlorosulfonic acid / 2 h / -78 - 0 °C

3.1: ammonia / water; ethyl acetate

4.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2 h / 75 °C / Heating / reflux

5.1: 1,2-bis-(chlorodimethylsilyl)ethane; triethylamine / tetrahydrofuran / 20 °C

5.2: -78 - -15 °C

With chlorosulfonic acid; trimethylsilyl cyanide; 1,2-bis-(chlorodimethylsilyl)ethane; hydroxylamine hydrochloride; ammonia; sodium acetate; triethylamine; zinc(II) iodide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;