ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate
• CAS No.: 406487-00-1
• Molecular Formula: C₂₈H₃₀F₃N₃O₈S₃
• Molecular Weight: 689.755
• Mol file: 406487-00-1.mol

Synonyms:ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate

Chemical Property of ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate

There total 1 articles about ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-oxopiperidin-1-yl)sulfonyl]thiophene-3-carboxylate (406486-99-5) + (3-aminophenyl)trifluoromethyl sulfone (426-59-5) → ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate (406487-00-1)

Guidance literature:

ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-oxopiperidin-1-yl)sulfonyl]thiophene-3-carboxylate; (3-aminophenyl)trifluoromethyl sulfone; In 1,1,2,2-tetrachloroethylene; for 17h; Heating / reflux;

With sodium cyanoborohydride; In 1,1,2,2-tetrachloroethylene; at 23 ℃; for 60h;

Reference yield: 100.0%

ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate (406487-00-1) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxamide

Guidance literature:

In methanol; for 8h; Heating / reflux;

Reference yield: 96.0%

ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylate (406487-00-1) → 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-{3-[(trifluoromethyl)sulfonyl]anilino}piperidin-1-yl)sulfonyl]thiophene-3-carboxylic acid

Guidance literature:

With sodium hydroxide; In methanol; water; at 45 ℃; for 2h;

upstream raw materials:

ethyl 5-{[(3-methoxybenzoyl)amino]methyl}-2-[(4-oxopiperidin-1-yl)sulfonyl]thiophene-3-carboxylate

(3-aminophenyl)trifluoromethyl sulfone