3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

Base Information

Chemical Name:3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil
CAS No.:1332758-15-2
Molecular Formula:C₄₂H₄₈N₂O₆Si
Molecular Weight:704.938
Hs Code.:

Synonyms:3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

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Chemical Property of 3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

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Technology Process of 3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

There total 1 articles about 3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3587-60-8
Benzyloxymethyl chloride

: 130860-12-7
2'-O-(tert-butyldimethylsilyl)-3'-deoxy-5'-O-trityluridine

: 1332758-15-2
3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol202124b

Reference yield: 85.0%

: 1332758-15-2
3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

: 1332758-16-3
3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-β-D-ribo-pentofuranosyl]uracil

Guidance literature:: With acetic acid; In water; at 60 ℃; for 3h;
DOI:10.1021/ol202124b

Reference yield:

: 1332758-15-2
3-(benzyloxymethyl)-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(triphenylmethyl)-β-D-ribopentofuranosyl]uracil

: 1332758-20-9
C₅₅H₇₉N₉O₁₃Si

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / water / 3 h / 60 °C

2: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Inert atmosphere

4: iodonium di(2,4,6-collidinium) triflate / acetonitrile / 0.5 h / -20 °C / Inert atmosphere

5: copper(l) iodide; caesium carbonate; (1R,2R)-(+)-N,N'-dimethyl-1,2-diphenyl-ethylenediamine / tetrahydrofuran / 8 h / 70 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; iodonium di(2,4,6-collidinium) triflate; iodine; caesium carbonate; (1R,2R)-(+)-N,N'-dimethyl-1,2-diphenyl-ethylenediamine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol202124b