3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

Base Information

Chemical Name:3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid
CAS No.:1381849-13-3
Molecular Formula:C₃₃H₄₅O₇PSi
Molecular Weight:612.775
Hs Code.:

Synonyms:3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

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Chemical Property of 3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

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Technology Process of 3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

There total 5 articles about 3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1381849-12-2
dibenzyl (4-((tert-butyldimethylsilyl)oxy)-3,5-dimethyl-2-(2-methyl-4-oxobutan-2-yl)phenyl)phosphate

: 1381849-13-3
3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

Guidance literature:: dibenzyl (4-((tert-butyldimethylsilyl)oxy)-3,5-dimethyl-2-(2-methyl-4-oxobutan-2-yl)phenyl)phosphate; With sodium chlorite; sodium dihydrogenphosphate; water; dihydrogen peroxide; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; acetonitrile; pH=1 - 2; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.034

Reference yield:

: 1381849-11-1
dibenzyl (4-((tert-butyldimethylsilyl)oxy)-2-(4-hydroxy-2-methylbutan-2-yl)-3,5-dimethylphenyl)phosphate

: 1381849-13-3
3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; sodium chlorite; water; dihydrogen peroxide / acetonitrile / 0 - 20 °C / Inert atmosphere

2.2: pH 1 - 2 / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; water; dihydrogen peroxide; pyridinium chlorochromate; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2012.04.034

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1381849-13-3
3-(6-((bis(benzyloxy)phosphoryl)oxy)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylphenyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.1: sodium dihydrogenphosphate; sodium chlorite; water; dihydrogen peroxide / acetonitrile / 0 - 20 °C / Inert atmosphere

5.2: pH 1 - 2 / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; water; dihydrogen peroxide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.034