N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

Base Information

Chemical Name:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide
CAS No.:1607465-33-7
Molecular Formula:C₂₃H₁₈FN₇S
Molecular Weight:443.507
Hs Code.:

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

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Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

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Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

There total 5 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1607465-29-1
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzamide

: 1607465-33-7
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; at 85 ℃; for 12h; Sealed tube;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1607465-42-8
2-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isoindoline-1,3-dione

: 1607465-33-7
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 5 h / 20 °C / Reflux

2.1: triethylamine / dichloromethane / 0.33 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C / Sealed tube

With Lawessons reagent; hydrazine hydrate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1607465-43-9
(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methanamine

: 1607465-33-7
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluorobenzothioamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.33 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C / Sealed tube

With Lawessons reagent; triethylamine; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/j.bmc.2014.03.022