Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

Base Information

• Chemical Name: Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-
• CAS No.: 614750-82-2
• Molecular Formula: C14H12N4O
• Molecular Weight: 252.275
• Hs Code.: 2933990090
• Mol file: 614750-82-2.mol

Synonyms:Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-;1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridine-6-yl-ethanone;Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl- 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridine-6-yl-ethanone;1-(6-methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylethanone

Chemical Property of Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

Chemical Property:

• PKA: 2.62±0.10(Predicted)
• PSA: 60.15000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 1.85810
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-1-(6-methylpyridin-2-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

There total 2 articles about Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate (614750-85-5) + [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde (614750-81-1) → 1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone (614750-82-2)

Guidance literature:

diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate; [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde; With caesium carbonate; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 16h;

With hydrogenchloride; In water; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2011.08.064

Reference yield:

6-methyl-2-pyridinecarboxaldehyde (1122-72-1) → 1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone (614750-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ziconium(IV) oxychloride octahydrate / 1 h / 20 °C

2.1: caesium carbonate / isopropyl alcohol; tetrahydrofuran / 20 °C

2.2: 1 h

2.3: pH 7 - 8

With ziconium(IV) oxychloride octahydrate; caesium carbonate; In tetrahydrofuran; isopropyl alcohol;

Reference yield: 92.0%

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone (614750-82-2) → 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (356560-84-4)

Guidance literature:

With hydrogen bromide; dimethyl sulfoxide; at 60 - 70 ℃; for 2h;

upstream raw materials:

diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

[1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde

6-methyl-2-pyridinecarboxaldehyde

Downstream raw materials:

C₂₂H₁₆FN₇S

C₂₂H₁₆ClN₇S

C₂₃H₁₉N₇S

C₂₃H₁₆F₃N₇S