3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Base Information

Chemical Name:3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide
CAS No.:1325706-40-8
Molecular Formula:C₂₁H₂₀FN₃O₅S₂
Molecular Weight:477.537
Hs Code.:

Synonyms:3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Suppliers and Price of 3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

There total 8 articles about 3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 745053-64-9
5-fluoro-1,3-thiazol-2-amine hydrochloride

: 1325708-35-7
3-(6-cyclopropanesulfonylpyridin-3-yloxy)-5-isopropoxybenzoic acid

: 1325706-40-8
3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 752242-26-5
methyl 3-hydroxy-5-isopropoxybenzoate

: 1325706-40-8
3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / ISOPROPYLAMIDE / 8 h / Reflux

2: sodium hydroxide; water / tetrahydrofuran; methanol / 8 h / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 40771-41-3
2-mercapto-5-chloro-pyridine

: 1325706-40-8
3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 - 25 °C

3.1: potassium tert-butylate / tert-butyl alcohol / 18 h / 20 °C

4.1: caesium carbonate / ISOPROPYLAMIDE / 8 h / Reflux

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 8 h / 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With potassium tert-butylate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; tert-butyl alcohol;