2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

Base Information

Chemical Name:2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene
CAS No.:1034864-63-5
Molecular Formula:C₂₆H₂₅F₂N₇
Molecular Weight:473.528
Hs Code.:

Synonyms:2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

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Chemical Property of 2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

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Technology Process of 2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

There total 3 articles about 2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1034864-69-1
2,5-difluoro-4-methylaminobenzaldehyde

: 23491-49-8
2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline

: 1034864-63-5
2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

Guidance literature:: With sodium hydrogensulfite; In ethanol; water; for 16h; Heating / reflux;

Reference yield:

: 23623-05-4
4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>-2-nitroaniline

: 1034864-63-5
2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 5% palladium over charcoal / methanol; ethyl acetate / 3 - 5 h / 760.05 Torr

2: sodium hydrogensulfite / ethanol; water / 16 h / Heating / reflux

With hydrogen; sodium hydrogensulfite; 5% palladium over charcoal; In methanol; ethanol; water; ethyl acetate;

Reference yield:

: 98349-22-5
2,4,5-trifluorobenzonitrile

: 1034864-63-5
2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 3 h

2.1: diisobutylaluminium hydride / diethyl ether; toluene / 16 h / 20 °C

2.2: 1 h / 0 °C

2.3: 1 h

3.1: sodium hydrogensulfite / ethanol; water / 16 h / Heating / reflux

With diisobutylaluminium hydride; sodium hydrogensulfite; In diethyl ether; ethanol; water; toluene;