23623-05-4

Basic information

• Product Name: NA
• Synonyms: 4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-2-nitroaniline;4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>-2-nitroaniline
• CAS NO: 23623-05-4
• Molecular Formula: C18H20N6O2
• Molecular Weight: 352.396
• Mol File: 23623-05-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: NA(CAS DataBase Reference)
• NIST Chemistry Reference: NA(23623-05-4)
• EPA Substance Registry System: NA(23623-05-4)

Safety Data

• Hazardous Substances Data: 23623-05-4(Hazardous Substances Data)

Upstream product

• 165596-29-2 ethyl 4-amino-3-nitrobenzenecarboximidate 
• 54998-08-2 4-(4-methylpiperazino)-1,2-diaminobenzene 
• 6393-40-4 4-Amino 3-nitro-benzonitrile 
• 23491-48-7 5-(4-methylpiperazine-1-yl)-2-nitroaniline 
• 29289-18-7 N-(4-cyano-2-nitrophenyl)acetamide 
• 35704-19-9 N-(4-cyanophenyl)acetamide 
• 873-74-5 4-Aminobenzonitrile 
• 109-01-3 1-methyl-piperazine 
• 1635-61-6 5-chloro-2-nitroaniline 
• 308362-09-6 2-(4-acetamido-3-nitrophenyl)-5-(4-methylpiperazinyl)-1H-benzimidazole 
• 51818-98-5 4-acetamido-3-nitrobenzaldehyde 
• 184033-32-7 4-cyano-2-nitrotrifluoroacetanilide 

Downstream Products

• 23491-52-3 2-[2-(4-ethoxyphenyl)benzimidazol-5⁽⁶⁾-yl]-5⁽⁶⁾-(4-methylpiperazin-1-yl)benzimidazole 
• 23491-49-8 2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline 
• 1034864-63-5 2,5-difluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-62-4 5-dimethylamino-2-fluoro-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-54-4 4-dimethylamino-2-fluoro-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-56-6 2-fluoro-4-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-57-7 2-chloro-4-dimethylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-61-3 2-fluoro-5-methylamino-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-58-8 3-fluoro-4-methoxy-1-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)benzene 
• 1034864-59-9 4-fluoro-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl]benzimidazol-2'-yl}benzene 
• 23491-49-8 4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>benzene-1,2-diamine 

Relevant articles and documents

Di-(benzimidazole)-1, 2, 3-triazole derivative as well as preparation and application thereof in inflammatory dermatosis

The invention belongs to the technical field of drug small molecules, and particularly discloses a brand-new di-(benzimidazole)-1, 2, 3-triazole derivative as well as preparation and application of the brand-new di-(benzimidazole)-1, 2, 3-triazole derivative. The research finds that the brand new compound has an excellent drug effect and low toxic and side effects on the aspect of inflammatory dermatosis, and has a good application prospect in the aspect of drug development of the inflammatory dermatosis.

Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells

Cell-permeable small molecules that enhance the stability of the G-quadruplex (G4) DNA structures are currently among the most intensively pursued ligands for inhibition of the telomerase activity. Herein we report the design and syntheses of four novel benzimidazole-carbazole conjugates and demonstrate their high binding affinity to G4 DNA. S1 nuclease assay confirmed the ligand mediated G-quadruplex DNA protection. Additional evidence from Telomeric Repeat Amplification Protocol (TRAP-LIG) assay demonstrated efficient telomerase inhibition activity by the ligands. Two of the ligands showed IC 50 values in the sub-micromolar range in the TRAP-LIG assay, which are the best among the benzimidazole derivatives reported so far. The ligands also exhibited cancer cell selective nuclear internalization, nuclear condensation, fragmentation, and eventually antiproliferative activity in long-term cell viability assays. Annexin V-FITC/PI staining assays confirm that the cell death induced by the ligands follows an apoptotic pathway. An insight into the mode of ligand binding was obtained from the molecular dynamics simulations.

OLIGOHETEROAROMATIC LUMINISCENT ASSEMBLIES AS HIGH-AFFINITY DNA SEQUENCE-DIRECTED LIGANDS

The present invention provides a novel class of oligoheteroaromatic assemblies with luminescence characteristics and composition based on integrated polyheterocyclic polyamide oligomers of multiple nitrogen-containing heteroaromatic of the general formula (I) This novel class of compounds of the present invention is capable of binding to targeted DNA sequence in the minor groove, and thus is useful for genomics applications. In particular, the compounds of the invention binds to the DNA at a binding stoichiometry of 2: 1 ternary complexation with very high affinity and sequence selectivity.