4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

Base Information

Chemical Name:4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide
CAS No.:1352834-98-0
Molecular Formula:C₁₉H₁₅FN₄O₃S
Molecular Weight:398.418
Hs Code.:

Synonyms:4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

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Chemical Property of 4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

Chemical Property:

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Technology Process of 4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

There total 8 articles about 4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1352834-89-9
7-amino-4-(2-fluorophenyl)-9H-pyrido[3,4-b]indole-1-carboxamide

: 124-63-0
methanesulfonyl chloride

: 1352834-98-0
4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: With pyridine; In dichloromethane; at 20 - 50 ℃; for 1.5h; Sealed tube;

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352834-98-0
4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / tetrahydrofuran / 16 h / 20 °C

2.1: 7 h / 105 °C / Inert atmosphere

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

4.2: pH 10

4.3: 3.5 h / 110 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 20 °C

5.2: pH 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: pyridine / dichloromethane / 1.5 h / 20 - 50 °C / Sealed tube

With 4-methyl-morpholine; pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1352834-92-4
benzyl 3-(2-amino-1-(2-fluorophenyl)ethyl)-1H-indol-6-ylcarbamate

: 1352834-98-0
4-(2-fluorophenyl)-7-(methylsulfonamido)-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

1.2: pH 10

1.3: 3.5 h / 110 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 20 °C

2.2: pH 5

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 20 °C

5.1: pyridine / dichloromethane / 1.5 h / 20 - 50 °C / Sealed tube

With 4-methyl-morpholine; pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;