6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
• CAS No.: 112734-89-1
• Molecular Formula: C₉H₁₀N₄O₂
• Molecular Weight: 206.204
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30429280
• Wikidata: Q82242277
• Mol file: 112734-89-1.mol

Synonyms:112734-89-1;6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione;6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione;6-amino-1,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione;CERICNITRATE;SCHEMBL9040192;DTXSID30429280;HMS1772K02;AKOS009085625;CS-0451329;EN300-23866;AB00741607-01;Z166627734

Chemical Property of 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.641
• Boiling Point: 459.5°Cat760mmHg
• Flash Point: 231.7°C
• PSA: 82.91000
• Density: 1.403g/cm³
• LogP: -0.20440
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 206.08037557
• Heavy Atom Count: 15
• Complexity: 307

Purity/Quality:

97% ^*data from raw suppliers

6-Amino-1,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(C=C(C=N2)N)C(=O)N(C1=O)C

Technology Process of 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 6 articles about 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,3-dimethyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione (112734-86-8) → 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (112734-89-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr; Inert atmosphere;

DOI:10.1016/j.tet.2012.11.026

Reference yield: 71.6%

charcoal powder + 1,3-dimethyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione (112734-86-8) → 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (112734-89-1)

Guidance literature:

In methanol; Pd-C;

Reference yield:

6-amino-1-methyluracil (2434-53-9) → 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (112734-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / 1percent aq. NaOH, sodium nitromalonaldehyde / 2 h / 80 °C

2: 59 percent / 0.05 N aq. NaOH / methanol / 1 h / Ambient temperature

3: 84 percent / H₂, AcOH / 5percent Pd/C / ethanol; acetic acid

With sodium hydroxide; hydrogen; nitromalondialdehyde sodium salt; acetic acid; palladium on activated charcoal; In methanol; ethanol; acetic acid;

DOI:10.3987/COM-91-S100

upstream raw materials:

1,3-dimethyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione

6-amino-1-methyluracil

1-methyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione

6-Amino-1,3-dimethylbarbituric acid

Downstream raw materials:

6-benzylamino-1-methylpyrido<2,3-d>pyrimidine-2,4-dione

6-benzylideneimino-1-methylpyrido<2,3-d>pyrimidine-2,4-dione

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