(E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

Base Information

Chemical Name:(E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile
CAS No.:263567-53-9
Molecular Formula:C₂₃H₁₉F₃N₂O₃
Molecular Weight:428.411
Hs Code.:

Synonyms:(E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

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Chemical Property of (E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

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Technology Process of (E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

There total 8 articles about (E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 143-33-9,25596-52-5
sodium cyanide

: 263567-52-8
4-({3-[(E)-3-chloro-1-methyl-1-propenyl]phenoxy}methyl)-5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

: 263567-53-9
(E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

Guidance literature:: In water; acetonitrile; for 3h; Heating;
DOI:10.1021/jm990476x

Reference yield:

: 659-28-9
p-trifluoromethoxybenzaldehyde

: 263567-53-9
(E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: HCl gas / ethyl acetate / 3 h / 5 °C

2.1: POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: toluene; tetrahydrofuran / 48 h

5.1: DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

7.1: 66 percent / H₂O; acetonitrile / 3 h / Heating

With hydrogenchloride; phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; trichlorophosphate; In diethyl ether; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Chlorination / 7.1: cyanidation;
DOI:10.1021/jm990476x

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 263567-53-9
(E)-4-[3-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-3-pentenenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: toluene; tetrahydrofuran / 48 h

3.1: DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

5.1: 66 percent / H₂O; acetonitrile / 3 h / Heating

With phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; In diethyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: Chlorination / 5.1: cyanidation;
DOI:10.1021/jm990476x