(E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

Base Information

Chemical Name:(E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid
CAS No.:1006699-32-6
Molecular Formula:C₁₉H₂₂N₄O₂
Molecular Weight:338.409
Hs Code.:

Synonyms:(E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

Suppliers and Price of (E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

Chemical Property:

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Technology Process of (E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

There total 2 articles about (E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 843662-48-6
3-[(E)-2-carboxyvinyl]benzeneboronic acid

: 1006700-12-4
1-(6-chloropyrazin-2-yl)-4-methyl[1,4]diazepane

: 1006699-32-6
(E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In N,N-dimethyl-formamide; at 100 - 150 ℃; Microwave irradiation;
DOI:10.1021/jm801242y

Reference yield:

: 1006699-32-6
(E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

Guidance literature:

Reference yield: 66.5%

: 1006699-32-6
(E)-3-{3-[6-(4-methyl[1,4]diazepan-1-yl)pyrazin-2-yl]phenyl}acrylic acid

: 141-43-5
ethanolamine

: 1006699-58-6
(E)-N-(2-Hydroxy-ethyl)-3-{3-[6-(4-methyl-perhydro-1,4-diazepin-1-yl)-pyrazin-2-yl]-phenyl}-acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 40.5h;