ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Base Information

Chemical Name:ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate
CAS No.:1207340-08-6
Molecular Formula:C₂₉H₃₃N₃O₃
Molecular Weight:471.599
Hs Code.:

Synonyms:ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

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Chemical Property of ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

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Technology Process of ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

There total 5 articles about ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 890170-93-1
ethyl 4-(2-chloroethyl)-benzoate

: 1207339-99-8
4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

: 1207340-08-6
ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Guidance literature:: With triethylamine; sodium iodide; In butanone; for 12h; Reflux;

Reference yield:

: 748159-52-6
2H-pyrrolo[3,4-c]quinolin-4(5H)-one

: 1207340-08-6
ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 15 h / 90 °C

2.1: triethylamine; trichlorophosphate / 6 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

3.2: 1 h / 146 °C

4.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

5.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium iodide; trichlorophosphate; In methanol; acetic acid; N,N-dimethyl-formamide; butanone; paraffin oil;
DOI:10.1021/jm300573d

Reference yield:

: 66757-87-7
2-nitro-benzenepropanoic acid ethyl ester

: 1207340-08-6
ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / diethyl ether; dimethyl sulfoxide; paraffin oil / 0.42 h / 20 °C / Inert atmosphere

2.1: iron / acetic acid / 0.75 h / 85 °C

3.1: N,N-dimethyl-formamide / 15 h / 90 °C

4.1: triethylamine; trichlorophosphate / 6 h / 120 °C

5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

5.2: 1 h / 146 °C

6.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

7.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; iron; sodium hydride; triethylamine; sodium iodide; trichlorophosphate; In methanol; diethyl ether; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; paraffin oil;
DOI:10.1021/jm300573d