66757-87-7

Basic information

• Product Name: 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER;Ethyl 3-(2-Nitrophenyl)propanoate
• CAS NO: 66757-87-7
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• Mol File: 66757-87-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER(66757-87-7)
• EPA Substance Registry System: 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER(66757-87-7)

Safety Data

• Hazardous Substances Data: 66757-87-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Nitro-phenyl)-propionic acid ethyl ester is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 3-(2-Nitro-phenyl)-propionic acid ethyl ester is employed as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and functional groups enable the creation of effective compounds for crop protection and management.
Used in Fine Chemicals Industry:
3-(2-Nitro-phenyl)-propionic acid ethyl ester is utilized as a key building block in the synthesis of fine chemicals, including fragrances, dyes, and other specialty chemicals. Its versatility and reactivity contribute to the development of high-quality products with specific properties and applications.
Used in Research and Development:
3-(2-Nitro-phenyl)-propionic acid ethyl ester is extensively used in research and development settings to explore its potential applications and properties. Scientists and researchers employ 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER to investigate its reactivity, synthesis pathways, and its role in the creation of new and innovative chemical entities.

Upstream product

• 612-23-7 2-nitrobenzyl chloride 
• 105-36-2 ethyl bromoacetate 
• 623-48-3 ethyl iodoacetae 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 577-19-5 2-nitrophenyl bromide 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 64-17-5 ethanol 

Downstream Products

• 503272-01-3 4-(2-nitrophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1207339-98-7 4-[[1-(phenylmethyl)-4-piperidyl]methoxy]-2-methyl-2H-pyrrolo-[3,4-c]quinoline 
• 1207339-90-9 4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride 
• 1207339-87-4 2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline 
• 1207339-85-2 4-{[1-(2-phenyl)ethylpiperidine-4-yl]methoxy}-2-methyl-2H-pyrrolo[3,4-c]quinoline 
• 1207340-21-3 2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid 
• 1207340-10-0 C₂₇H₂₉N₃O₃ 
• 1207340-19-9 methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate 
• 1207340-08-6 ethyl 4-[2-[4-[[(2-ethyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate 
• 1207340-12-2 4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline 
• 1207340-17-7 4-[(1-(4-methoxymethylphenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline 

Relevant articles and documents

Deconstructive di-functionalization of unstrained, benzo cyclic amines by C-N bond cleavage using a recyclable tungsten catalyst

With H2WO4 as the catalyst and H2O2 as the oxidant, we herein report a deconstructive difunctionalization of the C-N bond in unstrained, benzo cyclic amines to generate an ester group and nitro group simultaneously. The preliminary mechanistic studies suggested that the corresponding hydroxamic acid is the key intermediate for this transformation. Importantly, with the utilization of this transformation, we achieved an interesting approach for the ring contraction of quinoline to indole, an example of scaffold hopping in a hetero-aromatic system.

Base directed palladium catalysed Heck arylation of acrolein diethyl acetal in water

The selective Heck arylation of acrolein diethyl acetal catalysed by [Pd(NH3)4]Cl2 in the presence of RAME-β-CD in water as solvent is described. Depending on the base (i.e. NaOAc or HN(i-Pr)2) good to high selectivity's towards, respectively, the cinnamaldehydes 2 or the 3-arylpropionic esters 1 were achieved. The results support that depending on the base different palladium intermediate complexes are formed. Using NaOAc, {[ArPdX(H2O)2]} complex is preferentially generated giving the cinnamaldehyde 2. On the other hand, in the presence of HN(i-Pr)2, a L-type ligand, [ArPdX(HN(i-Pr) 2(H2O)] or [ArPdX(HN(i-Pr)2(HN(i-Pr) 2)] will be generated leading to the formation of the 3-arylpropionic ester 1. For the last, coordinated amine participates very probably to the formation of the esters through intramolecular syn β-H elimination.

Original TDAE strategy using α-halocarbonyl derivatives

We report herein the selective C-C bond formation by the reaction of nitrobenzyl carbanions, formed via the TDAE strategy, with α-haloesters and α-haloamides. This reaction, extended in benzodioxole and dimethoxybenzene series provides new potentially CNS