1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine
CAS No.:886548-04-5
Molecular Formula:C₁₈H₁₃ClN₄O₂S
Molecular Weight:384.846
Hs Code.:

1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine

Synonyms:1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

There total 6 articles about 1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 886547-96-2
3-(2-chloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 74-88-4
methyl iodide

: 886548-04-5
1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.bmcl.2006.06.073

Reference yield:

: 880769-95-9
3-bromo-1-(benzenesulfonyl)-1H-pyrrolo [2,3-b]pyridine

: 886548-04-5
1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Pd(II)(dppf)2Cl₂; KOAc / tetrahydrofuran

2: 85 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane

3: 25 percent / LDA / tetrahydrofuran / -78 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2006.06.073

Reference yield:

: 886547-94-0
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 886548-04-5
1-benzenesulfonyl-3-(2-chloro-pyrimidin-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane

2: 25 percent / LDA / tetrahydrofuran / -78 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2006.06.073