2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

Base Information

Chemical Name:2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol
CAS No.:1357565-84-4
Molecular Formula:C₂₁H₂₄F₃NO₃
Molecular Weight:395.422
Hs Code.:

Synonyms:2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

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Chemical Property of 2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

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Technology Process of 2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

There total 3 articles about 2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 885096-37-7
1-(4-benzylmorpholin-2-yl)-2-(2-methoxyphenyl)-ethanone

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1357565-84-4
2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

Guidance literature:: 1-(4-benzylmorpholin-2-yl)-2-(2-methoxyphenyl)-ethanone; (trifluoromethyl)trimethylsilane; With cesium fluoride; In toluene; at 0 - 20 ℃; for 48h; Inert atmosphere;

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.jfluchem.2011.02.018

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 1357565-84-4
2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20 h / 0 - 20 °C

1.2: 1 h / 0 °C

2.1: magnesium / diethyl ether / 20 °C / Cooling with ice

2.2: 0 - 20 °C

2.3: 0.08 h / 0 °C

3.1: cesium fluoride / toluene / 48 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 0 - 20 °C

With magnesium; cesium fluoride; In diethyl ether; toluene;
DOI:10.1016/j.jfluchem.2011.02.018

Reference yield:

: 147767-51-9,126645-52-1
4-benzyl-2-cyanomorpholine

: 1357565-84-4
2-(4-benzyl-morpholin-2-yl)-1,1,1-trifluoro-3-(2-methoxyphenyl)-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 20 °C / Cooling with ice

1.2: 0 - 20 °C

1.3: 0.08 h / 0 °C

2.1: cesium fluoride / toluene / 48 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C

With magnesium; cesium fluoride; In diethyl ether; toluene;
DOI:10.1016/j.jfluchem.2011.02.018