Cyclopropanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1R,2R)-rel- (9CI)

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1R,2R)-rel- (9CI)
CAS No.:112575-35-6
Molecular Formula:C₅H₉NO₃
Molecular Weight:131.131
Hs Code.:
Mol file:112575-35-6.mol

Synonyms:Cyclopropanecarboxylicacid, 1-amino-2-(hydroxymethyl)-, trans-

Suppliers and Price of Cyclopropanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1R,2R)-rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1R,2R)-rel- (9CI)

Chemical Property:

PSA：83.55000
LogP:-0.51900

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1R,2R)-rel- (9CI)

There total 7 articles about Cyclopropanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1R,2R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (1RS,5RS)-1-amino-2-oxo-3-oxabicyclo<3.1.0>hexane hydrochloride

: 112575-35-6,127181-31-1,146453-45-4,153610-74-3
(E)-1-Amino-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

Guidance literature:: With sodium hydroxide; Ambient temperature;
DOI:10.1021/jo00056a020

Reference yield: 16.0%

: 112575-34-5
N-benzylidene-2,3-methanohomoserine γ-lactone

: 112575-35-6,127181-31-1,146453-45-4,153610-74-3
(E)-1-Amino-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

Guidance literature:: With hydrogenchloride; for 3h; Ambient temperature;
DOI:10.1021/jo00240a010

Reference yield:

: 134209-82-8
tert-butyl allyl malonate

: 112575-35-6,127181-31-1,146453-45-4,153610-74-3
(E)-1-Amino-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / tosyl azide, K₂CO₃ / acetonitrile / Ambient temperature

2: 76 percent / CuI*P(OEt)3 / toluene / 100 - 120 °C

3: 90 percent / trifluoroacetic acid (TFA) / CH₂Cl₂ / 5 h / 0 deg C to room temperature

4: 94 percent / NEt₃, diphenylphosphoryl azide / Heating

5: 90 percent / HCl / dioxane

6: 72 percent / 2.5 M aq. NaOH / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4-toluenesulfonyl azide; diphenylphosphoranyl azide; potassium carbonate; triethylamine; trifluoroacetic acid; triethylphosphite copper(I) iodide complex; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo00056a020