Propanedioic acid, diazo-, 1,1-dimethylethyl 2-propenyl ester

Base Information

Chemical Name:Propanedioic acid, diazo-, 1,1-dimethylethyl 2-propenyl ester
CAS No.:128541-09-3
Molecular Formula:C10H14N2O4
Molecular Weight:226.232
Hs Code.:

Synonyms:

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Chemical Property of Propanedioic acid, diazo-, 1,1-dimethylethyl 2-propenyl ester

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Technology Process of Propanedioic acid, diazo-, 1,1-dimethylethyl 2-propenyl ester

There total 1 articles about Propanedioic acid, diazo-, 1,1-dimethylethyl 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 128541-09-3
allyl tert-butyl 2-diazomalonate

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, DMAP

2: 93 percent / tosyl azide, K₂CO₃ / acetonitrile / Ambient temperature

With dmap; 4-toluenesulfonyl azide; potassium carbonate; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1021/jo00056a020

Reference yield:

: 128541-09-3
allyl tert-butyl 2-diazomalonate

: 112575-35-6,127181-31-1,146453-45-4,153610-74-3
(E)-1-Amino-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / CuI*P(OEt)3 / toluene / 100 - 120 °C

2: 90 percent / trifluoroacetic acid (TFA) / CH₂Cl₂ / 5 h / 0 deg C to room temperature

3: 94 percent / NEt₃, diphenylphosphoryl azide / Heating

4: 90 percent / HCl / dioxane

5: 72 percent / 2.5 M aq. NaOH / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; triethylphosphite copper(I) iodide complex; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jo00056a020

Reference yield:

: 128541-09-3
allyl tert-butyl 2-diazomalonate

: 127181-31-1,146453-45-4,153610-74-3
(1RS,2SR)-1-amino-2-(hydroxymethyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / CuI*P(OEt)3 / toluene / 100 - 120 °C

2: 98 percent / NH₃, MeOH / 6 h / Ambient temperature

3: imidazole (ImH) / CH₂Cl₂ / Ambient temperature

4: 75 percent / pyridine, Pb(OAc)4 (LTA) / Heating

5: 68 percent / tetrabutyl ammonium fluoride (TBAF) / tetrahydrofuran / Ambient temperature

6: 76 percent / HCl, m-cresol / dioxane / Ambient temperature

With pyridine; 1H-imidazole; lead(IV) acetate; hydrogenchloride; methanol; tetrabutyl ammonium fluoride; ammonia; 3-methyl-phenol; triethylphosphite copper(I) iodide complex; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jo00056a020