1-Phenyl-2,3,4,5-tetramethylphosphole

Base Information

• Chemical Name: 1-Phenyl-2,3,4,5-tetramethylphosphole
• CAS No.: 112549-07-2
• Molecular Formula: C14H17 P
• Molecular Weight: 216.263
• Mol file: 112549-07-2.mol

Synonyms:1-Phenyl-2,3,4,5-tetramethylphosphole;2,3,4,5-Tetramethyl-1-phenylphosphole

Chemical Property of 1-Phenyl-2,3,4,5-tetramethylphosphole

Chemical Property:

• PSA: 13.59000
• LogP: 4.86380

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-2,3,4,5-tetramethylphosphole

There total 6 articles about 1-Phenyl-2,3,4,5-tetramethylphosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,1-bis(cyclopentadienyl)-2,3,4,5-tetramethylzirconacyclopentadiene (84101-39-3) + Dichlorophenylphosphine (644-97-3) → zirconocene dichloride (1291-32-3) + 2,3,4,5-tetramethyl-1-phenylphosphole (112549-07-2)

Guidance literature:

In tetrahydrofuran; immediate react. in THF at room temp.; solvent removed; 1-phenyl-2,3,4,5-tetramethylphosphole extd. with hexane and purified by chromy. (alumina);

DOI:10.1021/ja00215a057

Reference yield: 78.0%

→ 2,3,4,5-tetramethyl-1-phenylphosphole (112549-07-2)

Guidance literature:

Reference yield:

dimethylacetylene (503-17-3) + Dichlorophenylphosphine (644-97-3) → 2,3,4,5-tetramethyl-1-phenylphosphole (112549-07-2)

Guidance literature:

With n-butyllithium; zirconocene dichloride; Yield given. Multistep reaction; 1) THF, -78 deg C; 2) THF, RT;

DOI:10.1021/ja00215a057

upstream raw materials:

dimethylacetylene

Dichlorophenylphosphine

1,1-bis(cyclopentadienyl)-2,3,4,5-tetramethylzirconacyclopentadiene

phenylphosphane

Downstream raw materials:

C₄(CH₃)4PC₆H₅Mo(CO)5

(C₄(CH₃)4PC₆H₅)2Mo(CO)4

(C₄(CH₃)4PC₆H₅)2Mo(CO)4

cis-[PtCl₂(1-phenyl-2,3,4,5-tetramethylphosphole)2]

Refernces

• 1、 Pagano, Justin K.,Ackley, Brandon J.,Waterman, Rory. "Evidence for Iron-Catalyzed α-Phosphinidene Elimination with Phenylphosphine". . p. 2554 - 2557. Retrieved 2018/02/27.
• 2、 Fagan, Paul J.,Nugent, William A.,Calabrese, Joseph C.. "Metallacycle transfer from zirconium to main group elements: A versatile synthesis of heterocycles". . p. 1880 - 1889. Retrieved 2007/10/02.