6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

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Chemical Name:6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one
CAS No.:1459229-99-2
Molecular Formula:C₂₄H₂₁F₃N₄O₃
Molecular Weight:470.451
Hs Code.:

Synonyms:6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

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Chemical Property of 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

There total 9 articles about 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1459230-33-1
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

: 1459229-99-2
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1459230-31-9
tert-butyl ((1r,3r)-1-(4-(5-bromo-4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)-3-hydroxy-3-methylcyclobutyl)carbamate

: 1459229-99-2
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 152941-57-6
2-iodofuran-3-carboxylic acid

: 1459229-99-2
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / 5 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

3: potassium carbonate; hydrogenchloride; copper(l) iodide / N,N-dimethyl-formamide / 68 h / 100 °C / Sealed tube

4: bromine / N,N-dimethyl-formamide / 0.5 h / 0 °C

5: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 1.5 h / 70 °C / Inert atmosphere

6: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.17 h / 80 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / Inert atmosphere; Reflux

8: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With hydrogenchloride; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;