6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

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Chemical Name:6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one
CAS No.:1459230-33-1
Molecular Formula:C₂₉H₂₉F₃N₄O₅
Molecular Weight:570.568
Hs Code.:

Synonyms:6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

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Chemical Property of 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

There total 8 articles about 6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1459230-31-9
tert-butyl ((1r,3r)-1-(4-(5-bromo-4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)-3-hydroxy-3-methylcyclobutyl)carbamate

: 17997-47-6
2-tri-n-butylstannylpyridine

: 1459230-33-1
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 152941-57-6
2-iodofuran-3-carboxylic acid

: 1459230-33-1
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 5 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

3: potassium carbonate; hydrogenchloride; copper(l) iodide / N,N-dimethyl-formamide / 68 h / 100 °C / Sealed tube

4: bromine / N,N-dimethyl-formamide / 0.5 h / 0 °C

5: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 1.5 h / 70 °C / Inert atmosphere

6: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.17 h / 80 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / Inert atmosphere; Reflux

With hydrogenchloride; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1459230-28-4
3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

: 1459230-33-1
6-(4-((1r,3r)-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-5-(pyridin-2-yl)-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / N,N-dimethyl-formamide / 0.5 h / 0 °C

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 1.5 h / 70 °C / Inert atmosphere

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.17 h / 80 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;