4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

Base Information

Chemical Name:4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile
CAS No.:1007232-80-5
Molecular Formula:C₁₆H₁₉N₃OS
Molecular Weight:301.412
Hs Code.:

Synonyms:4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

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Chemical Property of 4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

Chemical Property:

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Technology Process of 4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

There total 5 articles about 4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1007232-79-2
N-[1-ethyl-1-(hydroxymethyl)propyl]thiourea

: 20099-89-2
4-Cyanophenacyl bromide

: 1007232-80-5
4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

Guidance literature:: In ethanol; for 4h; Heating / reflux;

Reference yield:

: 189631-94-5
ethyl 2-[(diphenylmethylene)amino]-2-ethylbutanoate

: 1007232-80-5
4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water / diethyl ether / 15.75 h / 0 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 16.5 h / 20 °C / Heating / reflux

2.2: 2 h

3.1: tetrahydrofuran / 2.5 h / Heating / reflux

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 21 h / 20 °C

5.1: ethanol / 4 h / Heating / reflux

With hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; water; In tetrahydrofuran; methanol; diethyl ether; ethanol;

Reference yield:

: 189631-96-7
ethyl 2-amino-2-ethylbutanoate

: 1007232-80-5
4-(2-{[1-ethyl-1-(hydroxymethyl)propyl]amino}-1,3-thiazol-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 16.5 h / 20 °C / Heating / reflux

1.2: 2 h

2.1: tetrahydrofuran / 2.5 h / Heating / reflux

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 21 h / 20 °C

4.1: ethanol / 4 h / Heating / reflux

With lithium hydroxide; lithium aluminium tetrahydride; water; In tetrahydrofuran; methanol; diethyl ether; ethanol;